![]() ![]() Inactivation of the pSI circuit largely blocked diverse aggressive behaviors but not mating. Activation of pSI neurons projecting to the periaqueductal gray (PAG) increased aggressive arousal and robustly initiated/promoted all the types of aggressive behavior examined in an activity-level-dependent manner. Here, we found that posterior substantia innominata (pSI) neurons responded to several aggression-provoking cues with the graded activity of differential dynamics, predicting the aggressive state and the topography of aggression in mice. Neural circuits regulating specific forms of aggression under defined conditions have been described, but how brain circuits govern a general aggressive response remains unknown. Although aggressive behaviors are universal and essential for survival, “uncontrollable” and abnormal aggressive behaviors in animals or humans may have severe adverse consequences or social costs. ![]()
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January 2023
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